Ex-Vivo Lymphatic Perfusion System for Independently Controlling Pressure Gradient and Transmural Pressure in Isolated Vessels
Identifieur interne : 002B03 ( Main/Exploration ); précédent : 002B02; suivant : 002B04Ex-Vivo Lymphatic Perfusion System for Independently Controlling Pressure Gradient and Transmural Pressure in Isolated Vessels
Auteurs : Jeffrey A. Kornuta ; J. Brandon DixonSource :
- Annals of biomedical engineering [ 0090-6964 ] ; 2014.
Abstract
In addition to external forces, collecting lymphatic vessels intrinsically contract to transport lymph from the extremities to the venous circulation. As a result, the lymphatic endothelium is routinely exposed to a wide range of dynamic mechanical forces, primarily fluid shear stress and circumferential stress, which have both been shown to affect lymphatic pumping activity. Although various ex-vivo perfusion systems exist to study this innate pumping activity in response to mechanical stimuli, none are capable of independently controlling the two primary mechanical forces affecting lymphatic contractility: transaxial pressure gradient, Δ
Url:
DOI: 10.1007/s10439-014-1024-6
PubMed: 24809724
PubMed Central: 4437633
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003298
- to stream Pmc, to step Curation: 003297
- to stream Pmc, to step Checkpoint: 001B74
- to stream Ncbi, to step Merge: 006647
- to stream Ncbi, to step Curation: 006647
- to stream Ncbi, to step Checkpoint: 006647
- to stream Main, to step Merge: 002B07
- to stream Main, to step Curation: 002B03
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ex-Vivo Lymphatic Perfusion System for Independently Controlling Pressure Gradient and Transmural Pressure in Isolated Vessels</title><author><name sortKey="Kornuta, Jeffrey A" sort="Kornuta, Jeffrey A" uniqKey="Kornuta J" first="Jeffrey A." last="Kornuta">Jeffrey A. Kornuta</name></author><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24809724</idno><idno type="pmc">4437633</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437633</idno><idno type="RBID">PMC:4437633</idno><idno type="doi">10.1007/s10439-014-1024-6</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003298</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003298</idno><idno type="wicri:Area/Pmc/Curation">003297</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003297</idno><idno type="wicri:Area/Pmc/Checkpoint">001B74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001B74</idno><idno type="wicri:Area/Ncbi/Merge">006647</idno><idno type="wicri:Area/Ncbi/Curation">006647</idno><idno type="wicri:Area/Ncbi/Checkpoint">006647</idno><idno type="wicri:doubleKey">0090-6964:2014:Kornuta J:ex:vivo:lymphatic</idno><idno type="wicri:Area/Main/Merge">002B07</idno><idno type="wicri:Area/Main/Curation">002B03</idno><idno type="wicri:Area/Main/Exploration">002B03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ex-Vivo Lymphatic Perfusion System for Independently Controlling Pressure Gradient and Transmural Pressure in Isolated Vessels</title><author><name sortKey="Kornuta, Jeffrey A" sort="Kornuta, Jeffrey A" uniqKey="Kornuta J" first="Jeffrey A." last="Kornuta">Jeffrey A. Kornuta</name></author><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name></author></analytic><series><title level="j">Annals of biomedical engineering</title><idno type="ISSN">0090-6964</idno><idno type="eISSN">1573-9686</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">In addition to external forces, collecting lymphatic vessels intrinsically contract to transport lymph from the extremities to the venous circulation. As a result, the lymphatic endothelium is routinely exposed to a wide range of dynamic mechanical forces, primarily fluid shear stress and circumferential stress, which have both been shown to affect lymphatic pumping activity. Although various ex-vivo perfusion systems exist to study this innate pumping activity in response to mechanical stimuli, none are capable of independently controlling the two primary mechanical forces affecting lymphatic contractility: transaxial pressure gradient, Δ<italic>P</italic>, which governs fluid shear stress; and average transmural pressure, <italic>P</italic><sub>avg</sub>, which governs circumferential stress. Hence, the authors describe a novel ex-vivo lymphatic perfusion system (ELPS) capable of independently controlling these two outputs using a linear, explicit model predictive control (MPC) algorithm. The ELPS is capable of reproducing arbitrary waveforms within the frequency range observed in the lymphatics in vivo, including a time-varying Δ<italic>P</italic> with a constant <italic>P</italic><sub>avg</sub>, time-varying Δ<italic>P</italic> and <italic>P</italic><sub>avg</sub>, and a constant Δ<italic>P</italic> with a time-varying <italic>P</italic><sub>avg</sub>. In addition, due to its implementation of syringes to actuate the working fluid, a post-hoc method of estimating both the flow rate through the vessel and fluid wall shear stress over multiple, long (5 sec) time windows is also described.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><name sortKey="Kornuta, Jeffrey A" sort="Kornuta, Jeffrey A" uniqKey="Kornuta J" first="Jeffrey A." last="Kornuta">Jeffrey A. Kornuta</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002B03 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002B03 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4437633
|texte= Ex-Vivo Lymphatic Perfusion System for Independently Controlling Pressure Gradient and Transmural Pressure in Isolated Vessels
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24809724" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |